手法を比較

	異質的治療効果介入時系列分析 (HTE-ITS)	中断時系列分析（Interrupted Time Series, ITS）
分野	因果推論	因果推論
系統	Regression model	Regression model
提唱年	2000s–2010s	2002
提唱者	Extensions of Shadish, Cook & Campbell (2002) ITS framework; HTE formulation developed by Lopez Bernal and colleagues	Wagner, Soumerai, Zhang & Ross-Degnan (segmented regression); Bernal, Cummins & Gasparrini (tutorial)
種類	Quasi-experimental segmented regression with subgroup moderation	Quasi-experimental segmented regression
原典	Lopez Bernal, J., Cummins, S., & Gasparrini, A. (2017). Interrupted time series regression for the evaluation of public health interventions: a tutorial. International Journal of Epidemiology, 46(1), 348-355.	Bernal, J. L., Cummins, S., & Gasparrini, A. (2017). Interrupted time series regression for the evaluation of public health interventions: a tutorial. International Journal of Epidemiology, 46(1), 348-355.
別名	HTE-ITS, Subgroup ITS, Effect-modifier ITS, Segmented ITS with interaction	ITS analysis, segmented regression of time series, Kesintili Zaman Serisi (ITS) Analizi
関連	4	5
概要	Heterogeneous Treatment Effect Interrupted Time Series extends the standard ITS design to detect whether an intervention's effect on a time series differs systematically across subgroups or in response to unit-level moderators. Where ordinary ITS yields a single level-change and slope-change estimate, HTE-ITS adds interaction terms for a moderating variable, revealing who benefits more or less from the intervention and by how much.	Interrupted Time Series analysis is a quasi-experimental design that estimates the effect of a single, well-dated intervention by comparing the trajectory of an outcome before and after it occurs. Formalised as segmented regression by Wagner and colleagues (2002) and popularised as a public-health evaluation tutorial by Bernal, Cummins and Gasparrini (2017), it separates the intervention's impact into a change in level and a change in slope.