手法を比較

	f1/f2 類似度因子（Dissolution f1/f2 Similarity Factor）	ミカエリス・メンテン速度論
分野	薬理学	薬理学
系統	Process / pipeline	Process / pipeline
提唱年	1996	1913
提唱者	James Moore and Hector Flanner	Leonor Michaelis and Maud Menten
種類	similarity testing	mechanistic model
原典	Moore, J. W., & Flanner, H. H. (1996). Mathematical comparison of dissolution profiles. Pharmaceutical Technology, 20(6), 64-74.	Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369.
別名	f1, f2, similarity factor	MM kinetics, Michaelis constant, Vmax
関連	3	2
概要	The f1 and f2 factors are dimensionless statistical measures developed by Moore and Flanner to quantify the similarity between two dissolution profiles. Adopted by regulatory agencies (FDA, EMA) as the gold standard for comparing dissolution curves, these factors enable rapid assessment of whether formulation changes significantly impact drug release.	Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics.