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	Metodologia delle Superfici di Risposta Assistita da Simulazione	Metodologia della Superficie di Risposta Assistita dall'Ottimizzazione
Campo	Disegno sperimentale	Disegno sperimentale
Famiglia	Process / pipeline	Process / pipeline
Anno di origine	1951 (RSM); simulation integration widely adopted from 1980s onward	1951 (RSM); 1980 (desirability-function optimization formalized)
Ideatore	Box & Wilson (RSM foundation); Kleijnen and others for simulation-based extensions	Derringer & Suich (desirability function); Box & Wilson (RSM foundation)
Tipo	Experimental optimization method	Hybrid experimental-optimization framework
Fonte seminale	Myers, R. H., Montgomery, D. C., & Anderson-Cook, C. M. (2016). Response Surface Methodology: Process and Product Optimization Using Designed Experiments (4th ed.). Wiley. ISBN: 978-1118916025	Derringer, G., & Suich, R. (1980). Simultaneous optimization of several response variables. Journal of Quality Technology, 12(4), 214–219.
Alias	SA-RSM, simulation-based RSM, computer simulation RSM, metamodel-assisted RSM	OA-RSM, RSM with optimization, desirability-based RSM, multi-response RSM optimization
Correlati	6	5
Sintesi	Simulation-assisted response surface methodology (SA-RSM) combines computer simulation models — such as finite element analysis, computational fluid dynamics, or discrete-event simulation — with the statistical framework of response surface methodology to efficiently map, model, and optimize system responses. Instead of running physical experiments, the researcher executes simulation runs at design points prescribed by an RSM design, fits a polynomial metamodel (surrogate) to the simulation outputs, and uses that metamodel to locate optimal factor settings.	Optimization-assisted RSM couples a second-order response surface model with a mathematical optimization routine — most commonly Derringer and Suich's desirability function, but also genetic algorithms or gradient-based solvers — to locate the factor settings that simultaneously satisfy multiple quality or performance objectives. The result is a data-driven recommendation for optimal process or product conditions, supported by a polynomial model fitted to a structured experimental design.