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	Progettazione di Esperimenti Assistita da Simulazione	Latin Hypercube Sampling
Campo	Disegno sperimentale	Simulazione
Famiglia	Process / pipeline	Process / pipeline
Anno di origine	1970s–1990s (formalized with computer experimentation growth)	1979
Ideatore	Multiple contributors; systematized by Jack P.C. Kleijnen and Thomas J. Santner et al.	—
Tipo	Hybrid experimental-computational method	Stratified space-filling sampling design
Fonte seminale	Santner, T. J., Williams, B. J., & Notz, W. I. (2003). The Design and Analysis of Computer Experiments. Springer. ISBN: 978-0387954202	McKay, M.D., Beckman, R.J. & Conover, W.J. (1979). A Comparison of Three Methods for Selecting Values of Input Variables in the Analysis of Output from a Computer Code. Technometrics, 21(2), 239-245.
Alias	Simulation-based DoE, Virtual DoE, Computer-aided DoE, SA-DoE	LHS, Latin Hiperküp Örnekleme (LHS) ve Duyarlılık Analizi, stratified sampling design, space-filling design
Correlati	5	4
Sintesi	Simulation-assisted design of experiments (SA-DoE) integrates computational simulation tools — such as finite element analysis (FEA), computational fluid dynamics (CFD), or discrete-event simulation — with classical DoE principles to systematically explore the factor space of a system. Rather than running costly or hazardous physical trials, researchers execute a structured set of virtual experiments across selected factor combinations, then fit a surrogate model to the simulation outputs to understand main effects, interactions, and optimal settings.	Latin Hypercube Sampling (LHS) is a stratified space-filling design for computer experiments, introduced by McKay, Beckman, and Conover in 1979. It divides each input variable's range into equally probable strata and draws exactly one sample per stratum, ensuring that the full input space is covered with far fewer model evaluations than standard Monte Carlo simulation requires. It is routinely paired with global sensitivity analysis — particularly Sobol indices — to quantify how much each input drives output variability.