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| Analisi della Diversità del Microbioma Multi-Omica× | Analisi Metabolomica× | |
|---|---|---|
| Campo | Bioinformatica | Bioinformatica |
| Famiglia | Process / pipeline | Process / pipeline |
| Anno di origine≠ | 2010s–present | 1998–2002 |
| Ideatore≠ | Developed collectively; key frameworks by Le Cao et al. (mixOmics, 2017) and Argelaguet et al. (MOFA, 2018) | Oliver et al. (coining of 'metabolomics'); Oliver Fiehn (systematic framework) |
| Tipo≠ | Integrative computational pipeline | Quantitative omics pipeline |
| Fonte seminale≠ | Rohart, F., Gautier, B., Singh, A., & Le Cao, K.-A. (2017). mixOmics: An R package for 'omics feature selection and multiple data integration. PLOS Computational Biology, 13(11), e1005752. DOI ↗ | Fiehn, O. (2002). Metabolomics — the link between genotypes and phenotypes. Plant Molecular Biology, 48(1-2), 155–171. link ↗ |
| Alias | multi-omics microbiome profiling, integrated microbiome omics, multi-modal microbiome analysis, microbiome multi-omics integration | metabolome profiling, metabolic profiling, metabonomics, metabolite profiling |
| Correlati≠ | 5 | 6 |
| Sintesi≠ | Multi-omics microbiome diversity analysis integrates two or more omic data layers — such as metagenomics, metatranscriptomics, metabolomics, and metaproteomics — to characterise both the composition and functional activity of microbial communities. By linking taxonomic diversity metrics with molecular phenotype data, the approach uncovers how community structure translates into ecological and host-relevant functions that no single omic layer can reveal alone. | Metabolomics analysis is the large-scale, systematic measurement of small-molecule metabolites in a biological sample to characterise the metabolome — the complete set of metabolic intermediates and products present under defined conditions. By coupling high-throughput analytical platforms such as mass spectrometry (MS) or nuclear magnetic resonance (NMR) spectroscopy with multivariate statistics and pathway databases, metabolomics bridges the genotype–phenotype gap and captures the downstream functional output of genes, transcripts, and proteins in real time. |
| ScholarGateInsieme di dati ↗ |
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