विधियों की तुलना करें

	समय-श्रृंखला कॉपी संख्या भिन्नता विश्लेषण	जीनोम-वाइड एसोसिएशन स्टडी (GWAS)
क्षेत्र	जैव सूचना विज्ञान	जैव सूचना विज्ञान
परिवार	Process / pipeline	Process / pipeline
उद्भव वर्ष	2010s–present	2005–2007
प्रवर्तक	Developed from foundational CNV methods (Olshen et al. 2004; Ding et al. 2010) extended to longitudinal tumor genomics frameworks	Klein et al. (age-related macular degeneration GWAS, 2005); landmark scale: Wellcome Trust Case Control Consortium (2007)
प्रकार	Computational genomics pipeline	Observational genomic association study
मौलिक स्रोत	Dentro, S. C., et al. (2021). Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. Cell, 184(8), 2239-2254.	Wellcome Trust Case Control Consortium. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), 661–678.
उपनाम	longitudinal CNV analysis, temporal copy number analysis, time-series CNV profiling, serial CNV analysis	GWAS, genome-wide association analysis, whole-genome association study, WGAS
संबंधित	5	6
सारांश	Time-series copy number variation (CNV) analysis is a computational genomics pipeline that characterizes chromosomal gains and losses across multiple sequential samples from the same individual or tumor. By comparing copy number profiles at successive time points — such as diagnosis, mid-treatment, relapse — it reconstructs the clonal dynamics and evolutionary trajectories driving genome instability, enabling researchers to track how sub-populations expand, contract, or acquire new aberrations over time.	A genome-wide association study (GWAS) systematically tests hundreds of thousands to millions of single-nucleotide polymorphisms (SNPs) across the human genome for statistical association with a trait or disease. By comparing allele frequencies between cases and controls — or by regressing SNP genotypes on a quantitative phenotype — GWAS identifies genomic loci that harbor common genetic variants contributing to complex traits. Since its large-scale debut in 2007, GWAS has catalogued thousands of robust disease–variant associations across virtually every common human condition.