Comparer des méthodes

	Régression de Cox avec covariables variant dans le temps	Modèle conjoint pour données longitudinales et données de temps d'événement
Domaine	Analyse de survie	Analyse de survie
Famille	Survival analysis	Survival analysis
Année d'origine	1972	2004
Auteur d'origine	Cox, D. R. (extended formulation by Therneau & Grambsch)	Tsiatis, A.A. & Davidian, M.; Rizopoulos, D.
Type	Semi-parametric hazard regression model	Semiparametric regression model
Source fondatrice	Therneau, T. M. & Grambsch, P. M. (2000). Modeling Survival Data: Extending the Cox Model. Springer.	Rizopoulos, D. (2012). Joint Models for Longitudinal and Time-to-Event Data. CRC Press.
Alias	time-varying covariate Cox model, extended Cox model, Zamana Bağlı Kovaryatlı Cox Regresyonu	joint model, shared random effects model, longitudinal-survival joint model, Joint Model (Boylamsal + Sağkalım Birleşik Model)
Apparentées	4	5
Résumé	Time-dependent Cox regression is an extension of the standard Cox proportional hazards model, introduced through the counting-process formulation developed by Therneau and Grambsch (2000), that allows one or more predictor variables to take different values at different points in a subject's follow-up period. It is the method of choice whenever a covariate — such as a laboratory measurement, a medication dose, or a disease severity score — changes over time rather than remaining fixed from study entry.	The joint model for longitudinal and time-to-event data, formalised by Tsiatis and Davidian in 2004 and extended comprehensively by Rizopoulos in 2012, simultaneously estimates a mixed-effects model for repeatedly measured biomarkers and a survival model for the time to an event, linking the two processes through shared random effects. It resolves two major problems that simpler approaches cannot handle: informative dropout from longitudinal studies and the endogeneity of time-varying biomarkers used as covariates in a Cox model.