Comparer des méthodes

	Pharmacovigilance PRR/ROR	Modélisation pharmacodynamique de population
Domaine	Pharmacologie	Pharmacologie
Famille	Process / pipeline	Process / pipeline
Année d'origine	2002	1992
Auteur d'origine	Arne Melander and colleagues	Lewis Sheiner and Stephen Roush
Type	safety signal detection	dose-response modeling
Source fondatrice	Szarfman, A., Tonning, J. M., Doraiswamy, P. M., & Osgood, D. J. (2002). Pharmacovigilance in the post-marketing setting: establishing causal links between drugs and adverse events. Drug Safety, 25(9), 619-631.	Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57.
Alias	PRR, ROR, signal detection, adverse event monitoring	PopPD, population PD, hierarchical PD modeling
Apparentées	3	3
Résumé	Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) are statistical methods for detecting safety signals in spontaneous adverse event reporting databases. Developed and formalized by researchers in the early 2000s, these measures identify drug-adverse event associations that warrant further investigation.	Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction.