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| تحلیل غنیسازی مجموعه ژن سری زمانی× | تحلیل غنیسازی مجموعههای ژنی (GSEA)× | |
|---|---|---|
| حوزه | زیستاطلاعاتی | زیستاطلاعاتی |
| خانواده | Process / pipeline | Process / pipeline |
| سال پیدایش≠ | 2005 (GSEA foundation); time-series adaptations 2007–2014 | 2005 (seminal PNAS paper; predecessor concept in Mootha et al. 2003) |
| پدیدآور≠ | Extension of GSEA (Subramanian et al., 2005); time-series adaptations developed through maSigPro (Conesa lab) and related tools | Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha, Jill P. Mesirov, Todd R. Golub, Eric S. Lander et al. (Broad Institute) |
| نوع≠ | Gene set enrichment method for longitudinal omics data | Functional genomics / enrichment analysis |
| منبع بنیادین | Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550. DOI ↗ | Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550. DOI ↗ |
| نامهای دیگر | longitudinal GSEA, dynamic GSEA, time-course GSEA, TS-GSEA | GSEA, gene-set analysis, functional enrichment analysis, pathway-level enrichment |
| مرتبط≠ | 6 | 5 |
| خلاصه≠ | Time-series gene set enrichment analysis (TS-GSEA) extends the classical GSEA framework to detect biologically coordinated gene sets — pathways, gene ontology terms, or curated signatures — whose collective expression changes meaningfully over time. Rather than comparing two snapshots, it models the full temporal trajectory of gene expression to identify which functional programs are activated, suppressed, or dynamically remodelled during a biological process such as development, treatment response, or disease progression. | Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether a predefined set of genes — representing a biological pathway, process, or function — shows statistically significant, coordinated differences between two biological conditions. Unlike simple fold-change filtering, GSEA operates on all measured genes ranked by a correlation metric, detecting subtle but consistent shifts across an entire pathway even when no single gene passes a significance threshold. |
| ScholarGateمجموعهداده ↗ |
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