مقایسهٔ روشها
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| مونتاژ دی نوو ترانسکریپتوم× | جستجوی پروفایل HMMER× | |
|---|---|---|
| حوزه | زیستاطلاعاتی | زیستاطلاعاتی |
| خانواده | Process / pipeline | Process / pipeline |
| سال پیدایش≠ | 2011 | 1994 |
| پدیدآور≠ | Aviv Regev | Sean Eddy |
| نوع≠ | Sequence assembly pipeline | Probabilistic sequence search pipeline |
| منبع بنیادین≠ | Grabherr, M. G., Haas, B. J., Yassour, M., Levin, J. Z., Thompson, D. A., Amit, I., ... & Regev, A. (2011). Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nature Biotechnology, 29(7), 644-652. DOI ↗ | Krogh, A., Brown, M., Mian, I. S., Sjölander, K., & Haussler, D. (1994). Hidden Markov models in computational biology: applications to protein modeling. Journal of Molecular Biology, 235(5), 1501-1531. DOI ↗ |
| نامهای دیگر | transcriptome assembly, de novo assembly, RNA-Seq assembly | profile-hidden Markov model, HMM profile search, HMMER |
| مرتبط | 3 | 3 |
| خلاصه≠ | De novo transcriptome assembly reconstructs full-length messenger RNA sequences directly from sequencing reads without requiring a reference genome. Pioneered by Regev, Haas, and colleagues, this pipeline enables transcript discovery in non-model organisms and detection of novel isoforms, fusion genes, and splice variants. | HMMER profile search identifies distant protein sequence homologs using probabilistic models of protein families, known as profile Hidden Markov Models (HMMs). Developed by Eddy and colleagues, this method captures sequence variation patterns within protein families and detects homologs with far greater sensitivity than position-weight matrices or pairwise alignment. |
| ScholarGateمجموعهداده ↗ |
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