Differential pathway enrichment analysis
Differential pathway enrichment analysis identifies biological pathways whose enrichment signals differ significantly between two or more experimental conditions — for example, between two diseases, two treatments, or two cell types. Rather than asking which pathways are enriched in one condition, it asks which pathways show a statistically meaningful change in enrichment level across conditions, revealing condition-specific or context-dependent biology.
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- Wu, D., & Smyth, G. K. (2012). Camera: a competitive gene set test accounting for inter-gene correlation. Nucleic Acids Research, 40(17), e133. · DOI 10.1093/nar/gks461
- Väremo, L., Nielsen, J., & Nookaew, I. (2013). Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical inferences. Nucleic Acids Research, 41(8), 4378–4391. · DOI 10.1093/nar/gkt111
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