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| Modelo de Riesgos Competitivos de Fine-Gray× | Regresión de Cox con covariables dependientes del tiempo× | |
|---|---|---|
| Campo≠ | Estadística | Supervivencia |
| Familia≠ | Hypothesis test | Survival analysis |
| Año de origen≠ | 1999 | 1972 |
| Autor original≠ | Jason P. Fine & Robert J. Gray | Cox, D. R. (extended formulation by Therneau & Grambsch) |
| Tipo≠ | Subdistribution hazard regression | Semi-parametric hazard regression model |
| Fuente seminal≠ | Fine, J.P. & Gray, R.J. (1999). A Proportional Hazards Model for the Subdistribution of a Competing Risk. Journal of the American Statistical Association, 94(446), 496–509. DOI ↗ | Therneau, T. M. & Grambsch, P. M. (2000). Modeling Survival Data: Extending the Cox Model. Springer. DOI ↗ |
| Alias≠ | competing risks regression, subdistribution hazard model, Fine-Gray model, Fine-Gray Competing Risks Modeli | time-varying covariate Cox model, extended Cox model, Zamana Bağlı Kovaryatlı Cox Regresyonu |
| Relacionados≠ | 5 | 4 |
| Resumen≠ | The Fine-Gray model is a semiparametric regression method for survival data in which two or more mutually exclusive event types compete to occur first. Proposed by Fine and Gray in 1999, it models the subdistribution hazard of each event type directly, allowing covariates to be linked to the cumulative incidence function (CIF) — the quantity that actually answers 'what is the probability of experiencing event type k by time t?'. It corrects the well-known shortcoming of standard Cox regression, which ignores competing events and thereby overestimates cause-specific probabilities. | Time-dependent Cox regression is an extension of the standard Cox proportional hazards model, introduced through the counting-process formulation developed by Therneau and Grambsch (2000), that allows one or more predictor variables to take different values at different points in a subject's follow-up period. It is the method of choice whenever a covariate — such as a laboratory measurement, a medication dose, or a disease severity score — changes over time rather than remaining fixed from study entry. |
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