Process / pipelineRaman Spectroscopy
SERS
Surface-Enhanced Raman Spectroscopy (SERS) amplifies weak Raman signals by many orders of magnitude when analyte molecules are adsorbed on specially prepared metal (typically silver or gold) nanostructured surfaces. Discovered by Fleischmann, Hendra, and McQuillan in 1974, SERS enables detection of vibrational signatures of single molecules and ultra-trace contaminants, revolutionizing analytical chemistry and forensics.
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Sources
- Fleischmann, M., Hendra, P. J., & McQuillan, A. J. (1974). Raman spectra of pyridine adsorbed at a silver electrode. Chemical Physics Letters, 26(2), 163-166. DOI: 10.1016/0009-2614(74)85388-1 ↗
- Jeanmaire, D. L., & Van Duyne, R. P. (1977). Surface raman spectroelectrochemistry: Part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode. Journal of Electroanalytical Chemistry, 84(1), 1-20. DOI: 10.1016/S0022-0728(77)80224-6 ↗
- Kneipp, K., Wang, Y., Kneipp, H., Perelman, L. T., Itzkan, I., Dasari, R. R., & Feld, M. S. (1997). Single molecule detection using surface-enhanced Raman scattering (SERS). Physical Review Letters, 78(9), 1667-1670. DOI: 10.1103/PhysRevLett.78.1667 ↗