Central Sensitization Inventory

The Central Sensitization Inventory (CSI) is a 25-item self-report screening instrument developed by Mayer and colleagues in 2012 to identify patients with central sensitization—a condition characterized by amplification of pain signaling and hypersensitivity to sensory stimuli. The CSI captures the constellation of symptoms including widespread pain, sleep disturbance, cognitive dysfunction, and autonomic dysregulation associated with central sensitization syndromes such as fibromyalgia, chronic fatigue syndrome, and post-traumatic stress disorder.