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Crossover Randomized Controlled Trial
A crossover randomized controlled trial (crossover RCT) is an experimental design in which each participant receives all study interventions in a randomized sequence, separated by a washout period. Because every participant serves as their own control, within-subject variability is eliminated from the treatment comparison, yielding greater statistical power per participant than a parallel-group RCT of equal size.
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Sources
- Senn, S. (2002). Cross-over Trials in Clinical Research (2nd ed.). Wiley. ISBN: 978-0471496533
- Jones, B., & Kenward, M. G. (2003). Design and Analysis of Cross-Over Trials (2nd ed.). Chapman and Hall/CRC. ISBN: 978-1584883429
Related methods
Referenced by
Blocked Randomized Controlled TrialCluster Randomized Multi-Arm ExperimentCrossover A/B TestCrossover Adaptive ExperimentCrossover Control Group Experimental DesignCrossover Factorial ExperimentCrossover Field ExperimentCrossover Fractional Factorial ExperimentCrossover Full Factorial ExperimentCrossover Laboratory ExperimentCrossover multi-arm experimentCrossover Multiple Baseline DesignCrossover Natural ExperimentCrossover Pretest-Posttest Experimental DesignCrossover Solomon Four-Group DesignDouble-blind Multiple Baseline DesignFactorial Randomized Controlled TrialMulti-arm experimentPilot Randomized Controlled TrialSingle-blind Randomized Controlled Trial