Bayesian Box-Behnken Design — Bayesian RSM with Three-Level Structured Points

Bayesian Box-Behnken Design combines the classical Box-Behnken three-level design structure with Bayesian statistical inference to fit and optimize response surface models. It uses mid-edge and center points to efficiently estimate a second-order polynomial response surface while incorporating prior knowledge about model parameters and propagating uncertainty through to predictions and optimal factor settings. The approach is widely applied in engineering process optimization and formulation studies.