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Patch-Clamp/Evidence
Method evidence record

Patch-Clamp

Patch-clamp electrophysiology is a technique for measuring ionic currents through ion channels in cell membranes, developed by Neher and Sakmann in 1976. It enables direct observation of single-channel and whole-cell currents at millisecond resolution, making it essential for characterizing drug effects on ion channels and cardiac safety assessment.

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Source record

Citations copied verbatim from the method’s source record. No claim-level verification is inferred from them.

Patch-Clamp Electrophysiology
Taxonomic method record · process-pipeline / pharmacology
  • Neher, E., & Sakmann, B. (1976). Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature, 260(5554), 799-802. · DOI 10.1038/260799a0
  • Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Archiv, 391(2), 85-100. · DOI 10.1007/BF00656997
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Curated claims

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Related methods

Generated from the method graph and shown as machine-suggested relations — no evidence claim is inferred.

Same method familyMichaelis-Menten Kineticsmachine-suggested · Relational suggestion, not evidence.Same method familyPopulation Pharmacodynamicsmachine-suggested · Relational suggestion, not evidence.Same method familySchild Analysismachine-suggested · Relational suggestion, not evidence.

Evidence status

Sources recorded, not reviewed

Bibliographic sources are present. Claim-level evidence review has not been performed.

Sources

2 recorded citations, copied from the method source record.

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