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CAM Assay/Evidence
Method evidence record

CAM Assay

The chorioallantoic membrane (CAM) assay is a well-established in vivo model for studying angiogenesis (new blood vessel formation) and evaluating the pro- or anti-angiogenic properties of biomaterials, drugs, and bioactive molecules. Developed by Judah Folkman in the 1970s, the assay uses the highly vascularized CAM of developing chick embryos as a platform for implanting test materials and observing vascular response. The CAM provides a transparent, immunologically naive microenvironment with rapid and reproducible neovascularization, making it ideal for screening angiogenic potential and assessing biomaterial biocompatibility.

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Source record

Citations copied verbatim from the method’s source record. No claim-level verification is inferred from them.

Chorioallantoic Membrane Assay Angiogenesis and Biocompatibility
Taxonomic method record · process-pipeline / biomaterials
  • Folkman, J. (1974). Tumor angiogenesis: therapeutic implications. New England Journal of Medicine, 285(21), 1182-1186. · URL
  • Ribatti, D. (2016). The chick embryo chorioallantoic membrane (CAM) assay. Current Protocols in Immunology, 15, 12.1-12.13. · DOI 10.1016/j.reprotox.2016.11.004
  • Norris, C. S., Griffith, O. W., & Reid, L. M. (2003). The chorioallantoic membrane (CAM) as a model for angiogenesis. In Antiangiogenic Agents in Cancer Therapy. Humana Press, pp. 463-477. · URL
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Related methods

Generated from the method graph and shown as machine-suggested relations — no evidence claim is inferred.

Same method familyHemolysis Assaymachine-suggested · Relational suggestion, not evidence.Same method familyLive/Dead Assaymachine-suggested · Relational suggestion, not evidence.Same method familyScratch Wound Assaymachine-suggested · Relational suggestion, not evidence.Same method familyTranswell Assaymachine-suggested · Relational suggestion, not evidence.

Evidence status

Sources recorded, not reviewed

Bibliographic sources are present. Claim-level evidence review has not been performed.

Sources

3 recorded citations, copied from the method source record.

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