Process / pipelineClinical / epidemiology
Prospective Case-Crossover Design — Epidemiological Method
The prospective case-crossover design is an observational epidemiological study in which each case serves as their own control. Unlike the retrospective variant, exposures are recorded in real time as participants are followed forward, eliminating recall bias. It is particularly suited to investigating transient environmental or behavioral triggers of acute events such as myocardial infarction, asthma attacks, or road-traffic injuries.
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Sources
- Maclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI: 10.1093/oxfordjournals.aje.a115853 ↗
- Navidi, W., & Weinhandl, E. (2002). Risk set sampling strategies for case-crossover studies. Epidemiology, 13(1), 100–105. DOI: 10.1097/00001648-200201000-00015 ↗