Process / pipelineClinical / epidemiology

Meta-analytic Cox Proportional Hazards — Pooling Survival Estimates Across Studies

Meta-analytic Cox proportional hazards is a quantitative synthesis technique that pools log hazard ratios from multiple Cox regression survival analyses into a single, more precise estimate of the association between an exposure or treatment and a time-to-event outcome. It combines the inferential power of survival analysis with the evidence-aggregation logic of meta-analysis, making it the standard approach for summarising multi-study survival evidence in clinical and epidemiological research.

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Sources

  1. Tierney, J. F., Stewart, L. A., Ghersi, D., Burdett, S., & Sydes, M. R. (2007). Practical methods for incorporating summary time-to-event data into meta-analysis. Trials, 8(1), 16. DOI: 10.1186/1745-6215-8-16
  2. Parmar, M. K. B., Torri, V., & Stewart, L. (1998). Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine, 17(24), 2815–2834. DOI: 10.1002/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8

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Referenced by

ScholarGateMeta-analytic Cox proportional hazards (Meta-analytic Cox Proportional Hazards Model). Retrieved 2026-06-04 from https://scholargate.app/en/epidemiology/meta-analytic-cox-proportional-hazards