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Adaptivt klinisk forsøgsdesign

Adaptivt klinisk forsøgsdesign er et fleksibelt eksperimentelt rammeværk, formaliseret af Bauer og Köhne i 1994, hvor forudspecificerede regler tillader, at forsøget kan modificeres midtvejs — justering af stikprøvestørrelse, behandlingsarme eller randomiseringsforhold — baseret på akkumulerede interimdata, samtidig med at Type I-fejlraten kontrolleres stringent.

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Kilder

  1. Bauer, P. & Köhne, K. (1994). Evaluation of Experiments with Adaptive Interim Analyses. Biometrics, 50(4), 1029–1041. DOI: 10.2307/2533441
  2. FDA (2019). Adaptive Design Clinical Trials for Drugs and Biologics — Guidance for Industry. U.S. Food and Drug Administration. link

Sådan citerer du denne side

ScholarGate. (2026, June 1). Adaptive Design for Clinical Trials. ScholarGate. https://scholargate.app/da/experimental-design/adaptive-design

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Refereret af

ScholarGateAdaptive Clinical Trial Design (Adaptive Design for Clinical Trials). Hentet 2026-06-15 fra https://scholargate.app/da/experimental-design/adaptive-design · Datasæt: https://doi.org/10.5281/zenodo.20539026