Time-series ChIP-seq peak calling
Time-series ChIP-seq peak calling extends standard chromatin immunoprecipitation sequencing analysis to samples collected at multiple time points. By identifying and comparing protein-DNA binding peaks across a temporal dimension, the method reveals how transcription factor occupancy, histone modifications, or chromatin remodeler binding evolve during biological processes such as differentiation, circadian cycles, or stimulus response.
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- Landt, S. G., Marinov, G. K., Kundaje, A., Kheradpour, P., Pauli, F., Batzoglou, S., ... & Snyder, M. (2012). ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. Genome Research, 22(9), 1813–1831. · DOI 10.1101/gr.136184.111
- Haiminen, N., Karlebach, G., Kharchenko, P. V., & Lähdesmäki, H. (2018). TimeChIP: time-series peak calling for ChIP-seq data. Bioinformatics, 34(24), 4161–4167. · URL
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