Compara mètodes

	Anàlisi d'Enriquiment de Conjunts de Gens en Sèries Temporals	Anàlisi d'Enriquiment de Vies
Camp	Bioinformàtica	Bioinformàtica
Família	Process / pipeline	Process / pipeline
Any d'origen	2005 (GSEA foundation); time-series adaptations 2007–2014	2003–2005
Autor original	Extension of GSEA (Subramanian et al., 2005); time-series adaptations developed through maSigPro (Conesa lab) and related tools	Mootha et al. (2003); systematised by Subramanian et al. (2005)
Tipus	Gene set enrichment method for longitudinal omics data	Statistical functional annotation method
Font seminal	Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550.	Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550.
Àlies	longitudinal GSEA, dynamic GSEA, time-course GSEA, TS-GSEA	PEA, overrepresentation analysis, ORA, functional enrichment analysis
Relacionats	6	6
Resum	Time-series gene set enrichment analysis (TS-GSEA) extends the classical GSEA framework to detect biologically coordinated gene sets — pathways, gene ontology terms, or curated signatures — whose collective expression changes meaningfully over time. Rather than comparing two snapshots, it models the full temporal trajectory of gene expression to identify which functional programs are activated, suppressed, or dynamically remodelled during a biological process such as development, treatment response, or disease progression.	Pathway enrichment analysis (PEA) is a statistical approach that takes a list of genes or proteins of interest — typically derived from a differential expression or proteomics experiment — and identifies which pre-defined biological pathways or functional gene sets are represented more often than expected by chance. By mapping individual molecular changes onto curated pathway knowledge bases such as KEGG, Gene Ontology, or Reactome, PEA translates long gene lists into interpretable biological processes, making it a central tool in the post-analysis of high-throughput omics experiments.