Compara mètodes

	Anàlisi Filogenètica de Cèl·lules Individuals	Anàlisi de Variació del Nombre de Còpies
Camp	Bioinformàtica	Bioinformàtica
Família	Process / pipeline	Process / pipeline
Any d'origen	2014-2020 (rapid development period)	1998–2006
Autor original	Multiple groups; foundational tools: Trapnell et al. (Monocle, 2014), Jones et al. (Cassiopeia, 2020)	Pinkel et al. (array CGH); Redon et al. (genome-wide CNV map)
Tipus	Computational phylogenetic inference pipeline	Genomic structural variant detection pipeline
Font seminal	Jones, M. G., Khodaverdian, A., Quinn, J. J., Chan, M. M., Hussmann, J. A., Wang, R., Xu, C., Weissman, J. S., & Yosef, N. (2020). Inference of single-cell phylogenies from lineage tracing data using Cassiopeia. Genome Biology, 21(1), 92.	Redon, R., Ishikawa, S., Fitch, K. R., et al. (2006). Global variation in copy number in the human genome. Nature, 444(7118), 444–454.
Àlies	scPhylogeny, single-cell lineage tracing, clonal phylogenetics, single-cell tree inference	CNV analysis, copy number variant detection, CNV calling, somatic copy number alteration analysis
Relacionats	4	6
Resum	Single-cell phylogenetic analysis reconstructs evolutionary or developmental trees from single-cell sequencing data, tracing how individual cells diverged from a common ancestor. By leveraging somatic mutations, CRISPR-introduced barcodes, or copy-number changes as heritable characters, this method maps clonal relationships within tumors, developing tissues, or immune repertoires with unprecedented cellular resolution.	Copy number variation (CNV) analysis is a genomic pipeline for detecting regions where individuals carry fewer or more copies of a DNA segment than the reference genome. CNVs span kilobases to megabases and are a major class of structural variation implicated in cancer, neurodevelopmental disorders, and population diversity. The pipeline typically processes SNP array intensities or read-depth signals from whole-genome sequencing, applies segmentation algorithms, calls gain and loss events, and annotates them against gene and clinical databases.