方法证据记录
Solid Dispersion
Solid dispersion is a formulation technique where a poorly soluble drug is molecularly dispersed in a hydrophilic polymer matrix, improving aqueous solubility and bioavailability. Introduced by Chiou and Riegelman in 1971, solid dispersions remain a key strategy for overcoming solubility-limited absorption.
源记录
引文逐字复制自方法源记录。这些引文不代表任何层级的验证。
Solid Dispersion Formulation Technology
分类方法记录 · process-pipeline / pharmacology
- Chiou, W. L., Riegelman, S. (1971). Pharmaceutical applications of solid dispersions. Journal of Pharmaceutical Sciences, 60(9), 1281-1302. · URL
- Vasconcelos, T., Sarmento, B., & Costa, P. (2007). Solid dispersions as strategy to improve oral bioavailability of poorly water soluble drugs. Drug Discovery Today, 12(23-24), 1068-1075. · DOI 10.1016/j.drudis.2007.09.005
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