方法证据记录
Pharmacokinetic Compartment Model
The pharmacokinetic compartment model represents the body as one or more hypothetical compartments interconnected by first-order rate processes, describing how a drug is absorbed, distributed, and eliminated over time. Systematized by Gibaldi and Perrier in 1982, these models use ordinary differential equations to characterize plasma concentration-time profiles. They are the cornerstone of drug development, dosage regimen design, and regulatory submission pharmacokinetic analyses.
源记录
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Compartmental Pharmacokinetic Models
分类方法记录 · regression-model / pharmacometrics
- Gibaldi, M., & Perrier, D. (1982). Pharmacokinetics (2nd ed.). Marcel Dekker. · ISBN 978-0-8247-1042-2
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