方法证据记录
Allometric PK Scaling
Allometric scaling is a mathematical approach for predicting human pharmacokinetics from preclinical animal data using body weight relationships. Developed systematically by Mordenti and colleagues in the late 1980s, it enables rational first-in-human dose prediction without assuming species-specific metabolic differences.
源记录
引文逐字复制自方法源记录。这些引文不代表任何层级的验证。
Allometric Pharmacokinetic Scaling
分类方法记录 · process-pipeline / pharmacology
- Mordenti, J., & Chappell, W. (1989). The use of allometric scaling in toxicokinetic studies. Fundamental and Applied Toxicology, 13(2), 335-346. · URL
- Feng, M. R., Chiang, S. T., & Grammatoglou, G. (2011). Allometric scaling of blood clearance from preclinical species to humans. Journal of Pharmaceutical and Biomedical Analysis, 21(2), 195-205. · URL
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