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| UHDRS：统一亨廷顿病评定量表× | 多发性硬化症功能复合量表× | |
|---|---|---|
| 领域 | 神经病学 | 神经病学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 1996 | 1999 |
| 提出者≠ | Huntington Study Group | Gary Cutter, Richard Rudick, and NMSS Consortium |
| 类型≠ | Clinician-rated and performance-based | Clinician-administered performance test |
| 开创性文献≠ | Huntington Study Group (1996). Unified Huntington's Disease Rating Scale: Reliability and consistency. Movement Disorders, 11(2), 136-142. link ↗ | Cutter, G. R., Baier, M. L., Rudick, R. A., et al. (1999). Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Multiple Sclerosis, 5(4), 244-250. DOI ↗ |
| 别名≠ | UHDRS, Huntington's Rating Scale | MS Functional Composite |
| 相关 | 4 | 4 |
| 摘要≠ | The Unified Huntington's Disease Rating Scale (UHDRS) is the comprehensive, multidomain assessment instrument for Huntington's disease, a neurodegenerative disorder caused by expanded CAG trinucleotide repeats. Developed by the Huntington Study Group in 1996, the UHDRS measures motor, cognitive, functional, and psychiatric manifestations of disease. The UHDRS is the gold-standard outcome measure in Huntington's disease clinical trials and longitudinal natural history studies. | The Multiple Sclerosis Functional Composite (MSFC) is an objective, performance-based assessment of MS-related disability capturing three key functional domains: lower extremity mobility, upper extremity coordination, and cognitive/processing speed. Developed in 1999 by the National MS Society and adopted widely in clinical trials, the MSFC provides quantifiable endpoints complementing the Expanded Disability Status Scale (EDSS). The three-component design addresses EDSS limitations by including cognition and standardizing measurement via timed tasks. |
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