方法对比
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| 时间序列蛋白质组学分析× | 多组学蛋白质组学分析× | |
|---|---|---|
| 领域 | 生物信息学 | 生物信息学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 2000s (quantitative framework: Gygi et al. 1999; time-series designs: 2004–2010) | 2010s (integrative multi-omics frameworks emerged ~2012–2019) |
| 提出者≠ | Multiple groups; Gygi et al. (1999) established quantitative proteomics; time-series designs emerged in the 2000s with LC-MS/MS workflows | Le Cao, K.-A. and colleagues (mixOmics/DIABLO framework); broader field rooted in Aebersold & Mann proteomics work |
| 类型≠ | Quantitative longitudinal omics pipeline | Integrative computational pipeline |
| 开创性文献≠ | Lemeer, S., & Heck, A. J. R. (2012). The phosphoproteomics data explosion. Current Opinion in Chemical Biology, 16(1–2), 1–8. link ↗ | Rohart, F., Gautier, B., Singh, A., & Le Cao, K.-A. (2017). mixOmics: An R package for omics feature selection and multiple data integration. PLOS Computational Biology, 13(11), e1005752. DOI ↗ |
| 别名 | longitudinal proteomics, temporal proteomics, dynamic proteomics, time-course proteomics | integrative proteomics, multi-omics proteomics integration, proteogenomics multi-omics, cross-omics proteomics |
| 相关 | 6 | 6 |
| 摘要≠ | Time-series proteomics analysis quantifies protein abundance across two or more ordered time points to reveal how the proteome changes dynamically in response to stimuli, developmental stages, or disease progression. By combining mass spectrometry-based protein quantification with statistical models designed for temporal data, the method identifies proteins with significant expression trends, oscillatory patterns, or delayed responses that cannot be detected in single time-point studies. | Multi-omics proteomics analysis integrates protein abundance data from mass spectrometry with at least one additional omics layer — such as genomics, transcriptomics, or metabolomics — to build a systems-level view of biological regulation. Rather than analyzing proteins in isolation, this approach correlates proteomic profiles with upstream molecular events (e.g., DNA variants, mRNA levels) and downstream functional readouts (e.g., metabolite concentrations), enabling discovery of regulatory drivers that single-omics analyses would miss. |
| ScholarGate数据集 ↗ |
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