方法对比
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| 含时变协变量的Cox回归× | Kaplan-Meier生存估计量× | |
|---|---|---|
| 领域 | 生存分析 | 生存分析 |
| 方法族 | Survival analysis | Survival analysis |
| 起源年份≠ | 1972 | 1958 |
| 提出者≠ | Cox, D. R. (extended formulation by Therneau & Grambsch) | Kaplan, E. L. & Meier, P. |
| 类型≠ | Semi-parametric hazard regression model | Non-parametric survival estimator |
| 开创性文献≠ | Therneau, T. M. & Grambsch, P. M. (2000). Modeling Survival Data: Extending the Cox Model. Springer. DOI ↗ | Kaplan, E. L. & Meier, P. (1958). Nonparametric Estimation from Incomplete Observations. Journal of the American Statistical Association, 53(282), 457–481. DOI ↗ |
| 别名 | time-varying covariate Cox model, extended Cox model, Zamana Bağlı Kovaryatlı Cox Regresyonu | product-limit estimator, km curve, kaplan-meier sağkalım analizi |
| 相关≠ | 4 | 2 |
| 摘要≠ | Time-dependent Cox regression is an extension of the standard Cox proportional hazards model, introduced through the counting-process formulation developed by Therneau and Grambsch (2000), that allows one or more predictor variables to take different values at different points in a subject's follow-up period. It is the method of choice whenever a covariate — such as a laboratory measurement, a medication dose, or a disease severity score — changes over time rather than remaining fixed from study entry. | The Kaplan-Meier estimator, introduced by Kaplan and Meier in 1958, is a non-parametric method that estimates the survival curve — the probability of remaining event-free over time — from right-censored time-to-event data. The log-rank test is the companion procedure used to compare survival curves between groups. |
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