方法对比
并排查看您选择的方法；存在差异的行会高亮显示。
| 治疗药物监测 (TDM)× | 群体药代动力学× | |
|---|---|---|
| 领域 | 定量药理学 | 定量药理学 |
| 方法族 | Regression model | Regression model |
| 起源年份≠ | 1988 | 1977 |
| 提出者≠ | Reynold Spector et al. | Sheiner, Rosenberg & Marathe |
| 类型≠ | Clinical measurement and dose-optimization framework | Nonlinear mixed-effects regression model |
| 开创性文献≠ | Spector, R., Park, G. D., Johnson, G. F., & Vesell, E. S. (1988). Therapeutic drug monitoring. Clinical Pharmacology & Therapeutics, 43(4), 345–353. DOI ↗ | Sheiner, L. B., Rosenberg, B., & Marathe, V. V. (1977). Estimation of population characteristics of pharmacokinetic parameters from routine clinical data. Journal of Pharmacokinetics and Biopharmaceutics, 5(5), 445–479. DOI ↗ |
| 别名 | Drug Level Monitoring, Serum Drug Level Monitoring, Clinical Pharmacokinetic Monitoring, İlaç Düzeyi İzlemi | PopPK, Nonlinear Mixed-Effects Modeling, NONMEM Approach, Popülasyon Farmakokinetiği |
| 相关≠ | 3 | 2 |
| 摘要≠ | Therapeutic Drug Monitoring (TDM) is a clinical pharmacokinetic practice in which drug concentrations are measured in a patient's blood to guide individualized dosing. It applies principally to drugs with narrow therapeutic windows—where the margin between efficacy and toxicity is small—such as aminoglycosides, vancomycin, cyclosporine, and antiepileptics. Developed as a formal discipline in the 1980s, TDM integrates measured concentrations with pharmacokinetic modeling to calculate patient-specific dose regimens. | Population Pharmacokinetics (PopPK) is a nonlinear mixed-effects modeling framework that characterizes how drugs are absorbed, distributed, metabolized, and eliminated across a patient population, estimating both typical population parameters and the magnitude of between-subject variability. Introduced by Sheiner, Rosenberg, and Marathe in 1977, it enables parameter estimation from sparse, routinely collected clinical data—making it indispensable in drug development, regulatory submissions, and individualized dosing. |
| ScholarGate数据集 ↗ |
|
|