方法对比

	单盲多臂试验	自适应实验
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	Mid-to-late 20th century	1940s–1970s (sequential foundations); formalised in clinical and behavioural research by 1980s–2000s
提出者	Developed within the clinical trials tradition; formalized by Friedman, Furberg, and DeMets and others in the 20th century	Abraham Wald (sequential analysis foundation); expanded by Robbins, Armitage, and others
类型	Controlled experimental design	Experimental research design
开创性文献	Friedman, L. M., Furberg, C. D., & DeMets, D. L. (2010). Fundamentals of Clinical Trials (4th ed.). Springer. ISBN: 978-1441915849	Chow, S. C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman and Hall/CRC. ISBN: 978-1584886761
别名	single-masked multi-arm trial, single-blind multi-group experiment, unidirectional blinding multi-arm design, SB-MAT	adaptive design, response-adaptive randomization, adaptive trial, adaptive randomization
相关	5	5
摘要	A single-blind multi-arm experiment is a controlled experimental design that simultaneously compares three or more treatment conditions while blinding participants — but not investigators — to their group assignment. This configuration reduces response bias driven by participants' expectations, preserves operational feasibility when full blinding is impractical, and allows direct pairwise and omnibus comparisons across multiple arms within a single study.	An adaptive experiment is an experimental design in which pre-specified rules allow the protocol to be modified — such as reallocating participants to better-performing arms, stopping early for efficacy or futility, or changing sample size — based on accumulating interim data, while maintaining statistical validity. Adaptive designs are widely used in clinical trials, behavioural economics, and online platform testing to improve efficiency and ethics without sacrificing inferential rigour.