方法对比

	单盲析因实验	单盲随机对照试验
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	Factorial design: 1926; single-blinding as systematic practice: mid-20th century	1948 (formalized); single-blind variant established in mid-20th century clinical trial methodology
提出者	Fisher, R. A. (factorial design); blinding practices formalized in clinical trials literature (20th century)	Bradford Hill and colleagues (MRC streptomycin trial, 1948); blinding conventions codified in CONSORT guidelines
类型	Controlled experimental design	Experimental design — blinded randomized trial
开创性文献	Montgomery, D. C. (2017). Design and Analysis of Experiments (9th ed.). Wiley. ISBN: 978-1119113478	Schulz, K. F., Altman, D. G., Moher, D., & CONSORT Group. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMJ, 340, c332.
别名	single-masked factorial trial, single-blind factorial design, SB factorial experiment	single-masked RCT, single-blind RCT, single-blind trial, SB-RCT
相关	5	5
摘要	A single-blind factorial experiment combines factorial design — simultaneously varying two or more independent factors across all their level combinations — with single-blinding, in which participants are unaware of which treatment condition they have been assigned to while researchers and administrators remain unmasked. This design enables efficient estimation of main effects and interactions while reducing participant-side response bias.	A single-blind randomized controlled trial (SB-RCT) is a rigorous experimental design in which participants are randomly assigned to treatment or control conditions while remaining unaware of which condition they have received. Investigators, outcome assessors, and data analysts are not blinded. By masking participants, the design eliminates placebo and nocebo response biases on the participant side, while preserving investigator flexibility to administer and monitor the intervention.