方法对比

	唾液生物标志物分析	DMFT指数
领域	口腔医学	口腔医学
方法族	Process / pipeline	Process / pipeline
起源年份	2000s+ (clinical application)	1938
提出者	Multiple innovators (Giannobile, Malamud, et al.)	Henry Klein, Cedric Palmer, and James Knutson
类型	Laboratory and point-of-care diagnostics	Epidemiological index
开创性文献	Giannobile, W. V., McDevitt, J. T., Niedbala, R. S., Malamud, D., & Prozorovsky, T. (2009). Translating molecular diagnostics into clinical practice: Designing the next generation of oral health technologies. Advances in Dental Research, 23(1), 80-89.	Klein, H., Palmer, C. E., & Knutson, J. W. (1938). Studies on dental caries: I. Dental status and dental needs of elementary school children. Public Health Reports, 53(32), 1259-1274.
别名	saliva testing, salivary diagnostics, oral biomarker assessment	DMF index, DMF score, DMFT score
相关	3	4
摘要	Salivary biomarker analysis detects protein, molecular, or microbial markers in saliva that indicate oral and systemic disease. Salivary diagnostics assess risk and activity of dental caries, periodontal disease, oral cancer, and other conditions. Biomarkers include antimicrobial proteins (lysozyme, lactoferrin), inflammatory mediators (interleukins, TNF-alpha), cariogenic bacteria (Streptococcus mutans), and virulence factors. Point-of-care saliva testing offers rapid, non-invasive alternatives to conventional laboratory methods, enabling chairside diagnosis and personalized risk assessment.	The DMFT (Decayed, Missing due to caries, Filled) Index is a standardized epidemiological measure of dental caries experience in permanent dentition. Developed by Klein, Palmer, and Knutson in 1938, it quantifies the number of permanent teeth that are decayed, missing due to caries, or filled due to caries. The DMFT Index remains the most widely used caries index globally, enabling comparison of oral health across populations and tracking disease burden over time.