方法对比

	回顾性巢式病例对照研究	回顾性队列研究
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1973 (formal description); widely adopted in epidemiology from 1980s onward	Mid-20th century (widely formalized 1950s–1970s)
提出者	Nested case-control formalized by Mantel (1973); retrospective application via historical cohort records	Systematic use attributed to early 20th-century occupational epidemiology; formalized in modern epidemiological theory by Brian MacMahon and others
类型	Observational analytic study design	Observational analytic study
开创性文献	Mantel, N. (1973). Synthetic retrospective studies and related topics. Biometrics, 29(3), 479–486.	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
别名	retrospective NCC, nested case-control within retrospective cohort, case-control nested in historical cohort, nested CCR	historical cohort study, non-concurrent cohort study, retrospective follow-up study, historical prospective study
相关	5	6
摘要	A retrospective nested case-control study is an efficient observational design in which cases and matched controls are sampled from within an already-assembled retrospective cohort. Exposure data are retrieved from historical records only for selected participants, dramatically reducing data-collection costs while retaining most of the analytic power of the full cohort. It is widely used in pharmacoepidemiology, occupational health, and disease-registry research.	A retrospective cohort study assembles a group of individuals who share a common starting point and reconstructs their exposure history and subsequent outcomes entirely from pre-existing records. Because the data have already been collected before the study begins, the design is far faster and cheaper than a prospective cohort; however, the researcher must work with whatever information was recorded at the time rather than collecting purpose-built measurements.