方法对比

	回顾性病例对照研究	回顾性队列研究
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1950s–1960s (formal methodology)	Mid-20th century (widely formalized 1950s–1970s)
提出者	Jerome Cornfield; formalized by Brian MacMahon and others in mid-20th-century epidemiology	Systematic use attributed to early 20th-century occupational epidemiology; formalized in modern epidemiological theory by Brian MacMahon and others
类型	Observational analytical study	Observational analytic study
开创性文献	Schlesselman, J. J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195029338	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
别名	case-control study, retrospective case-referent study, case-referent design, trohoc study	historical cohort study, non-concurrent cohort study, retrospective follow-up study, historical prospective study
相关	5	6
摘要	A retrospective case-control study identifies individuals who already have an outcome of interest (cases) and a comparable group without it (controls), then looks backward in time using existing records to determine prior exposure to a suspected risk factor. The primary measure of association is the odds ratio. This design is especially efficient for studying rare diseases or outcomes with long latency periods, since the outcome has already occurred before the study begins.	A retrospective cohort study assembles a group of individuals who share a common starting point and reconstructs their exposure history and subsequent outcomes entirely from pre-existing records. Because the data have already been collected before the study begins, the design is far faster and cheaper than a prospective cohort; however, the researcher must work with whatever information was recorded at the time rather than collecting purpose-built measurements.