方法对比

	前瞻性剂量-反应分析	剂量-反应分析
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1965 (Hill's criteria); widely applied through 1980s–present	Conceptual roots 16th century; modern epidemiological application mid-20th century
提出者	Bradford Hill (causal criteria including dose-response, 1965); formalized in modern epidemiology by Rothman, Greenland and others	Paracelsus (conceptual foundation); formalized by John Snow and later Bradford Hill
类型	Analytical epidemiological study design	Quantitative analytical method
开创性文献	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
别名	prospective exposure-response analysis, prospective trend analysis, forward-looking dose-response study, prospective gradient analysis	exposure-response analysis, concentration-response modeling, dose-response modeling, DRA
相关	4	4
摘要	Prospective dose-response analysis is an epidemiological approach that measures exposure levels in a defined population before outcomes occur, then quantifies how the risk or magnitude of an outcome changes systematically as exposure increases. By collecting exposure data prospectively, researchers can establish temporal sequence, reduce recall bias, and assess whether a biological gradient — one of Hill's classic causal criteria — exists between the agent of interest and a health outcome.	Dose-response analysis quantifies the relationship between the magnitude of an exposure (the dose) and the probability or rate of an outcome (the response). It is a core analytical strategy in epidemiology and toxicology, providing evidence that increasing exposure systematically increases — or decreases — the risk of disease. A demonstrated dose-response gradient is one of Bradford Hill's classic criteria supporting causal inference.