方法对比

	务实病例对照研究	队列研究
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	1950s–1960s (classical); pragmatic framing 1967–2000s	Mid-20th century (formal epidemiological design codified ~1950s)
提出者	Evolved from classical case-control methodology (Dorn, 1954; Cornfield, 1956); pragmatic framing formalized by Schwartz & Lellouch (1967)	Doll & Hill (British Doctors Study, 1951); Snow (cholera, 1854)
类型	Observational epidemiological study design	Observational longitudinal study design
开创性文献	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641	Rothman, K. J., Greenland, S., & Lash, T. L. (2008). Modern Epidemiology (3rd ed.). Lippincott Williams & Wilkins. ISBN: 978-0781755641
别名	real-world case-control study, pragmatic case-control design, effectiveness case-control study, PCCS	longitudinal study, follow-up study, panel study, incidence study
相关	6	6
摘要	A pragmatic case-control study is an observational design that compares individuals who have developed a disease or outcome (cases) with those who have not (controls), using data collected under routine real-world conditions rather than strictly controlled experimental settings. Exposure histories are reconstructed from clinical records, registries, or administrative databases. The design is chosen when a conventional explanatory case-control study would be impractical, unethical, or too narrow to inform actual clinical or public-health decisions.	A cohort study assembles a group of individuals who share a common starting point — typically freedom from the outcome of interest — and follows them over time to observe who develops the outcome. By comparing incidence rates between exposed and unexposed subgroups, researchers can estimate relative risk and absolute risk differences. Cohort studies are the gold-standard observational design for measuring disease incidence and establishing temporal relationships between exposure and outcome.