方法对比
并排查看您选择的方法；存在差异的行会高亮显示。
| 药物警戒PRR/ROR× | Caco-2 细胞渗透性测定× | |
|---|---|---|
| 领域 | 药理学 | 药理学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 2002 | 1989 |
| 提出者≠ | Arne Melander and colleagues | Ingrid Hidalgo |
| 类型≠ | safety signal detection | absorption screening |
| 开创性文献≠ | Szarfman, A., Tonning, J. M., Doraiswamy, P. M., & Osgood, D. J. (2002). Pharmacovigilance in the post-marketing setting: establishing causal links between drugs and adverse events. Drug Safety, 25(9), 619-631. link ↗ | Hidalgo, I. J., Raub, T. J., & Borchardt, R. T. (1989). Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96(3), 736-749. DOI ↗ |
| 别名≠ | PRR, ROR, signal detection, adverse event monitoring | Caco-2 assay, intestinal permeability, ADME screening |
| 相关 | 3 | 3 |
| 摘要≠ | Proportional Reporting Ratio (PRR) and Reporting Odds Ratio (ROR) are statistical methods for detecting safety signals in spontaneous adverse event reporting databases. Developed and formalized by researchers in the early 2000s, these measures identify drug-adverse event associations that warrant further investigation. | The Caco-2 assay is an in vitro model system using human colon carcinoma cell monolayers to screen drug intestinal permeability. Developed by Hidalgo and colleagues in 1989, Caco-2 cells differentiate into an epithelial barrier resembling intestinal mucosa, enabling rapid assessment of drug absorption potential and identification of transporter-mediated transport. |
| ScholarGate数据集 ↗ |
|
|