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| 膜片钳电生理学× | 群体药效学模型× | |
|---|---|---|
| 领域 | 药理学 | 药理学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 1976 | 1992 |
| 提出者≠ | Erwin Neher and Bert Sakmann | Lewis Sheiner and Stephen Roush |
| 类型≠ | ion channel screening | dose-response modeling |
| 开创性文献≠ | Neher, E., & Sakmann, B. (1976). Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature, 260(5554), 799-802. DOI ↗ | Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57. link ↗ |
| 别名 | patch clamp, whole-cell recording, ion channel assay | PopPD, population PD, hierarchical PD modeling |
| 相关 | 3 | 3 |
| 摘要≠ | Patch-clamp electrophysiology is a technique for measuring ionic currents through ion channels in cell membranes, developed by Neher and Sakmann in 1976. It enables direct observation of single-channel and whole-cell currents at millisecond resolution, making it essential for characterizing drug effects on ion channels and cardiac safety assessment. | Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction. |
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