方法对比

	多中心病例系列研究	病例系列
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	Mid-to-late 20th century (collaborative multi-site reporting common by 1970s–1980s)	Longstanding; systematized in 20th century clinical research
提出者	Evolved from single-center case series practice; formalized in 20th century clinical reporting	Historical clinical practice; formalized in modern evidence-based medicine literature
类型	Observational descriptive study	Observational descriptive study
开创性文献	Dekkers, O. M., Vandenbroucke, J. P., Cevallos, M., Renehan, A. G., Altman, D. G., & Egger, M. (2012). COSMOS-E: Guidance on conducting systematic reviews and meta-analyses of observational studies of etiology and prognosis. PLoS Medicine, 9(2), e1001175.	Case series. Wikipedia.
别名	multi-site case series, multicentre case series, collaborative case series, multi-institutional case series	case series report, clinical case series, consecutive case series, patient series
相关	5	5
摘要	A multicenter case series is an observational descriptive study in which consecutive or selected patients sharing a defined clinical condition are enrolled and followed at two or more independent clinical sites. By pooling cases across institutions, researchers achieve larger sample sizes and greater demographic and clinical diversity than a single-center series permits, enabling more reliable description of disease presentation, management patterns, and outcomes for rare or uncommon conditions.	A case series is a descriptive observational study that documents the characteristics, clinical course, and outcomes of a group of patients who share a common condition, exposure, or intervention. Unlike case reports, which focus on a single patient, a case series aggregates data across multiple patients (typically three or more) to identify patterns, generate hypotheses, and characterize rare or novel conditions — without a concurrent control group.