方法对比

	多中心病例报告	多中心病例系列研究
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	Long-standing practice; CARE guidelines formalized 2013	Mid-to-late 20th century (collaborative multi-site reporting common by 1970s–1980s)
提出者	Clinical medicine tradition; CARE guidelines by Gagnier et al.	Evolved from single-center case series practice; formalized in 20th century clinical reporting
类型	Observational descriptive study	Observational descriptive study
开创性文献	Gagnier, J. J., Kienle, G., Altman, D. G., Moher, D., Sox, H., & Riley, D. (2013). The CARE guidelines: Consensus-based clinical case reporting guideline development. Journal of Medical Case Reports, 7, 223.	Dekkers, O. M., Vandenbroucke, J. P., Cevallos, M., Renehan, A. G., Altman, D. G., & Egger, M. (2012). COSMOS-E: Guidance on conducting systematic reviews and meta-analyses of observational studies of etiology and prognosis. PLoS Medicine, 9(2), e1001175.
别名	multi-site case report, collaborative case report, multicentre case report, CARE multicenter report	multi-site case series, multicentre case series, collaborative case series, multi-institutional case series
相关	4	5
摘要	A multicenter case report is a structured clinical document describing one or a very small number of unusual patients observed across two or more independent healthcare institutions. By pooling observations from multiple sites, it overcomes the rarity barrier that prevents any single center from documenting an unusual presentation, adverse event, or novel treatment response — producing a richer, more externally valid account than a single-center report can offer.	A multicenter case series is an observational descriptive study in which consecutive or selected patients sharing a defined clinical condition are enrolled and followed at two or more independent clinical sites. By pooling cases across institutions, researchers achieve larger sample sizes and greater demographic and clinical diversity than a single-center series permits, enabling more reliable description of disease presentation, management patterns, and outcomes for rare or uncommon conditions.