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| 多组学蛋白质组学分析× | 代谢组学分析× | |
|---|---|---|
| 领域 | 生物信息学 | 生物信息学 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 2010s (integrative multi-omics frameworks emerged ~2012–2019) | 1998–2002 |
| 提出者≠ | Le Cao, K.-A. and colleagues (mixOmics/DIABLO framework); broader field rooted in Aebersold & Mann proteomics work | Oliver et al. (coining of 'metabolomics'); Oliver Fiehn (systematic framework) |
| 类型≠ | Integrative computational pipeline | Quantitative omics pipeline |
| 开创性文献≠ | Rohart, F., Gautier, B., Singh, A., & Le Cao, K.-A. (2017). mixOmics: An R package for omics feature selection and multiple data integration. PLOS Computational Biology, 13(11), e1005752. DOI ↗ | Fiehn, O. (2002). Metabolomics — the link between genotypes and phenotypes. Plant Molecular Biology, 48(1-2), 155–171. link ↗ |
| 别名 | integrative proteomics, multi-omics proteomics integration, proteogenomics multi-omics, cross-omics proteomics | metabolome profiling, metabolic profiling, metabonomics, metabolite profiling |
| 相关 | 6 | 6 |
| 摘要≠ | Multi-omics proteomics analysis integrates protein abundance data from mass spectrometry with at least one additional omics layer — such as genomics, transcriptomics, or metabolomics — to build a systems-level view of biological regulation. Rather than analyzing proteins in isolation, this approach correlates proteomic profiles with upstream molecular events (e.g., DNA variants, mRNA levels) and downstream functional readouts (e.g., metabolite concentrations), enabling discovery of regulatory drivers that single-omics analyses would miss. | Metabolomics analysis is the large-scale, systematic measurement of small-molecule metabolites in a biological sample to characterise the metabolome — the complete set of metabolic intermediates and products present under defined conditions. By coupling high-throughput analytical platforms such as mass spectrometry (MS) or nuclear magnetic resonance (NMR) spectroscopy with multivariate statistics and pathway databases, metabolomics bridges the genotype–phenotype gap and captures the downstream functional output of genes, transcripts, and proteins in real time. |
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