方法对比

	米氏动力学	群体药效学模型	Schild 分析
领域	药理学	药理学	药理学
方法族	Process / pipeline	Process / pipeline	Process / pipeline
起源年份	1913	1992	1947
提出者	Leonor Michaelis and Maud Menten	Lewis Sheiner and Stephen Roush	Henry Schild
类型	mechanistic model	dose-response modeling	antagonism quantification
开创性文献	Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369.	Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57.	Schild, H. O. (1947). pA, a new scale for the measurement of drug antagonism. Journal of Physiology, 106(3), 337-357.
别名	MM kinetics, Michaelis constant, Vmax	PopPD, population PD, hierarchical PD modeling	Schild plot, pA2
相关	2	3	3
摘要	Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics.	Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction.	Schild analysis is a quantitative method for characterizing competitive receptor antagonism developed by Henry Schild in 1947. It uses dose-response curves in the presence and absence of antagonist to estimate the antagonist affinity constant (pA2), enabling standardized comparison of antagonist potency across drugs and experimental systems.