方法对比

	荟对病例报告	病例系列
领域	流行病学	流行病学
方法族	Process / pipeline	Process / pipeline
起源年份	2000s–2010s (formalized methodology)	Longstanding; systematized in 20th century clinical research
提出者	Developed iteratively in clinical epidemiology; formalized guidance by Murad et al. (2018)	Historical clinical practice; formalized in modern evidence-based medicine literature
类型	Synthesis / secondary research design	Observational descriptive study
开创性文献	Murad, M. H., Sultan, S., Haffar, S., & Bazerbachi, F. (2018). Methodological quality and synthesis of case series and case reports. BMJ Evidence-Based Medicine, 23(2), 60–63.	Case series. Wikipedia.
别名	pooled case report analysis, systematic case report review, case report meta-analysis, MACR	case series report, clinical case series, consecutive case series, patient series
相关	3	5
摘要	A meta-analytic case report is a secondary research methodology that systematically identifies, appraises, and quantitatively or qualitatively pools data from multiple published individual case reports on the same clinical phenomenon. It is used most often when randomized trials or cohort data are unavailable — particularly for rare diseases, uncommon drug reactions, or novel presentations — and transforms isolated anecdotal observations into a more robust aggregate picture.	A case series is a descriptive observational study that documents the characteristics, clinical course, and outcomes of a group of patients who share a common condition, exposure, or intervention. Unlike case reports, which focus on a single patient, a case series aggregates data across multiple patients (typically three or more) to identify patterns, generate hypotheses, and characterize rare or novel conditions — without a concurrent control group.