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| Marginal Structural Model (MSM)× | G-计算（参数G-公式）× | |
|---|---|---|
| 领域 | 因果推断 | 因果推断 |
| 方法族 | Regression model | Regression model |
| 起源年份≠ | 2000 | 1986 |
| 提出者≠ | James M. Robins, Miguel A. Hernan, Babette Brumback | James M. Robins |
| 类型≠ | Causal model / semiparametric weighting | Parametric causal effect estimation |
| 开创性文献≠ | Robins, J. M., Hernan, M. A., & Brumback, B. (2000). Marginal structural models and causal inference in epidemiology. Epidemiology, 11(5), 550-560. DOI ↗ | Robins, J. M. (1986). A new approach to causal inference in mortality studies with sustained exposure periods: application to control of the healthy worker survivor effect. Mathematical Modelling, 7(9-12), 1393-1512. DOI ↗ |
| 别名≠ | MSM, MSM-IPTW, marginal structural Cox model, weighted structural model | G-formula, Parametric G-formula, Standardization |
| 相关≠ | 5 | 2 |
| 摘要≠ | A marginal structural model is a causal modeling framework designed to estimate the effect of a time-varying treatment in the presence of time-varying confounders that are themselves affected by prior treatment. By reweighting observations with inverse probability of treatment weights, MSMs create a pseudo-population in which confounding is eliminated, enabling unbiased estimation of causal treatment contrasts even when standard regression adjustments would fail. | G-computation is a causal inference method for estimating the effect of an intervention or treatment on an outcome from observational data. Developed by James M. Robins in 1986, it provides a parametric approach to standardization that can handle time-varying exposures and confounders. The method estimates what the population outcome would be under different intervention scenarios by utilizing fitted outcome models. |
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