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| 磁化传递比× | 神经元定向扩散与密度成像 (NODDI)× | |
|---|---|---|
| 领域 | 神经影像 | 神经影像 |
| 方法族 | Process / pipeline | Process / pipeline |
| 起源年份≠ | 1989 | 2012 |
| 提出者≠ | Stephen Wolff | Hui Zhang |
| 类型≠ | Tissue microstructure characterization | Microstructural white matter mapping |
| 开创性文献≠ | Wolff, S. D., & Balaban, R. S. (1989). Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Journal of Magnetic Resonance Imaging, 10(2), 135–148. DOI ↗ | Zhang, H., Schneider, T., Wheeler-Kingshott, C. A., & Alexander, D. C. (2012). NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage, 61(4), 1000–1016. DOI ↗ |
| 别名≠ | MTR, magnetization transfer, MT imaging | NODDI, neurite density mapping |
| 相关 | 3 | 3 |
| 摘要≠ | Magnetisation Transfer Ratio (MTR) is an MRI method that measures the exchange of magnetization between free water protons and protons bound to macromolecules (primarily myelin lipids and proteins). Introduced by Wolff and Balaban in 1989, MTR reflects tissue macromolecular content and is particularly sensitive to myelination, providing a non-invasive estimate of myelin density. | Neurite Orientation Dispersion and Density Imaging (NODDI) is a biophysical diffusion MRI model that quantifies microstructural properties of white matter: neurite density (axonal density), orientation dispersion (fiber coherence), and isotropic diffusion (free water or cerebrospinal fluid). Introduced by Zhang and colleagues in 2012, NODDI provides biologically interpretable metrics directly linking diffusion MRI signals to tissue microstructure. |
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