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| 机器学习辅助通路富集分析× | 随机森林× | |
|---|---|---|
| 领域≠ | 生物信息学 | 机器学习 |
| 方法族≠ | Process / pipeline | Machine learning |
| 起源年份≠ | 2010s–present | 2001 |
| 提出者≠ | Multiple groups; early integration of ML with PEA circa 2010s (e.g., Ma'ayan Lab, Greene Lab) | Breiman, L. |
| 类型≠ | Computational pipeline combining statistical enrichment with machine learning | Ensemble (bagging of decision trees) |
| 开创性文献≠ | Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma'ayan, A. (2013). Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics, 14, 128. link ↗ | Breiman, L. (2001). Random Forests. Machine Learning, 45, 5–32. DOI ↗ |
| 别名 | ML-assisted PEA, ML-based pathway analysis, machine learning pathway enrichment, ML-enhanced gene set enrichment | Rastgele Orman (Random Forest), rastgele orman, random decision forest, bagged tree ensemble |
| 相关≠ | 2 | 4 |
| 摘要≠ | Machine learning-assisted pathway enrichment analysis integrates classical statistical pathway enrichment methods — such as over-representation analysis or gene set enrichment analysis — with machine learning algorithms to improve sensitivity, handle high-dimensional omics data, and uncover non-linear biological patterns. The approach moves beyond ranking pathways by p-value alone, using ML models to weight gene contributions, distinguish signal from noise across many samples, and prioritize biologically meaningful pathways in complex datasets. | Random Forest is an ensemble learning method, introduced by Leo Breiman in 2001, that grows many decision trees on bootstrap samples of the data and combines their votes to produce strong classification and regression. By pooling many slightly different trees, it produces more accurate and more stable predictions than any single tree. |
| ScholarGate数据集 ↗ |
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