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双盲全因子实验×析因随机对照试验×
领域实验设计实验设计
方法族Process / pipelineProcess / pipeline
起源年份1935 (factorial foundations, Fisher); double-blind combined application from 1950s onward1926 (Fisher factorial foundations); 2000s–2010s (clinical factorial RCT formalization)
提出者Full factorial design: Ronald A. Fisher; double-blind masking: formalized in clinical research mid-20th centuryR. A. Fisher (factorial design foundations); adapted into clinical trials via MOST framework (Collins et al., 2014)
类型Controlled experimental design with maskingExperimental trial design
开创性文献Montgomery, D. C. (2017). Design and Analysis of Experiments (9th ed.). Wiley. ISBN: 978-1119492443Collins, L. M., Dziak, J. J., Kugler, K. C., & Trail, J. B. (2014). Factorial experiments: Efficient tools for evaluation of intervention components. American Journal of Preventive Medicine, 47(4), 498–504. DOI ↗
别名double-masked full factorial design, double-blind complete factorial experiment, blinded full factorial RCT, double-blind factorial trialFactorial RCT, factorial trial, multi-factor RCT, factorial experiment with randomization
相关46
摘要A double-blind full factorial experiment crosses every level of every independent variable to create all possible treatment combinations, while ensuring that neither participants nor outcome assessors know which condition each participant has been assigned to. This design simultaneously achieves comprehensive examination of main effects and all interactions, and protection against performance and detection bias through blinding — making it especially valuable in clinical, pharmacological, and behavioral research.A factorial randomized controlled trial (factorial RCT) is an experimental design in which participants are randomly assigned to every possible combination of two or more independent factors (treatments or intervention components) simultaneously. This allows researchers to estimate the main effect of each factor and their interactions within a single, efficient trial, rather than running separate experiments for each factor.
ScholarGate数据集
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  2. 2 来源
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  1. v1
  2. 2 来源
  3. PUBLISHED

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ScholarGate方法对比: Double-blind Full Factorial Experiment · Factorial Randomized Controlled Trial. 于 2026-06-19 检索自 https://scholargate.app/zh/compare