方法对比

	双盲全因子实验	区组完全析因实验
领域	实验设计	实验设计
方法族	Process / pipeline	Process / pipeline
起源年份	1935 (factorial foundations, Fisher); double-blind combined application from 1950s onward	1935 (Fisher); systematized through 20th-century DOE literature
提出者	Full factorial design: Ronald A. Fisher; double-blind masking: formalized in clinical research mid-20th century	R. A. Fisher (blocking principle); full factorial DOE tradition
类型	Controlled experimental design with masking	Experimental design
开创性文献	Montgomery, D. C. (2017). Design and Analysis of Experiments (9th ed.). Wiley. ISBN: 978-1119492443	Montgomery, D. C. (2017). Design and Analysis of Experiments (9th ed.). Wiley. ISBN: 978-1119113478
别名	double-masked full factorial design, double-blind complete factorial experiment, blinded full factorial RCT, double-blind factorial trial	blocked full factorial design, full factorial with blocking, complete factorial blocked design, BFF design
相关	4	4
摘要	A double-blind full factorial experiment crosses every level of every independent variable to create all possible treatment combinations, while ensuring that neither participants nor outcome assessors know which condition each participant has been assigned to. This design simultaneously achieves comprehensive examination of main effects and all interactions, and protection against performance and detection bias through blinding — making it especially valuable in clinical, pharmacological, and behavioral research.	A blocked full factorial experiment tests every combination of all factor levels while grouping experimental runs into homogeneous blocks to isolate a known nuisance variable. This design preserves the power to detect all main effects and interactions of the factors of interest while preventing batch-to-batch, day-to-day, or machine-to-machine variability from inflating experimental error.